2013 Fiscal Year Final Research Report
Involvement of pericytes-derived cyclophilin A in the development of insulin resistanse in the brain
| Project/Area Number |
23790113
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Research Collaborator |
KATAOKA Yasufumi 福岡大学, 薬学部, 教授 (70136513)
DOHGU Shinya 福岡大学, 薬学部, 准教授 (60399186)
MATSUMOTO Junichi 福岡大学, 薬学部, 助教 (10550064)
MACHIDA Takashi 福岡大学, 薬学部, 助教 (30586144)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳ペリサイト / cyclophilin A / 脳インスリン抵抗性 |
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| Research Abstract |
Brain pericytes in the microvasculature are periendothelial accessory structures of the blood-brain barrier (BBB). We previously demonstrated that pericytes increase insulin sensitivity in the hypothalamic neurons through soluble factors under the physiological conditions. However, under the pathological conditions such as diabetes mellitus (DM), a role of pericytes in hypothalamic insulin sensitivity remained obscure. The expression of cyclophilin A (CypA) and its receptor, CD147 in the brain and brain microvessels were increased in the obese mice with impaired glucose tolerance induced by high fat diet. CypA release from pericytes was much higher than that from other BBB-constituting cells under the physiological conditions. TNF-a increased CypA release from pericytes. The treatment of TNF-a combined with CypA decreased insulin sensitivity in the hypothalamic neurons. Therefore, pericytes and pericytal CypA could be involved in insulin resistance in the central nervous system.
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[Journal Article] Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells2013
Author(s)
Takata F, Dohgu S, Matsumoto J, Machida T, Kaneshima S, Matsuo M, Sakaguchi S, Takeshige Y, Yamauchi A, Kataoka Y
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Journal Title
Biochem Biophys Res Commun
Volume: 19,433(4)
Pages: 586-90
DOI
Peer Reviewed
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[Journal Article] In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties2013
Author(s)
Takata F, Dohgu S, Yamauchi A, Matsumoto J, Machida T, Fujishita K, Shibata K, Shinozaki Y, Sato K, Kataoka Y, Koizumi S
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Journal Title
PLoS One
Volume: 8(1)
Pages: 55166
DOI
Peer Reviewed
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[Journal Article] Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro2011
Author(s)
Takata F, Dohgu S, Matsumoto J, Takahashi H, Machida T, Wakigawa T, Harada E, Miyaji H, Koga M, Nishioku T, Yamauchi A, Kataoka Y
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Journal Title
J Neuroinflammation
Volume: 26
Pages: 106
DOI
Peer Reviewed
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