2013 Fiscal Year Final Research Report
Usefulness of the Rho/Rho kinase inhibitor to overcome perioperative spasm of coronary artery bypass graft in diabetes mellitus
| Project/Area Number |
23790114
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Kyushu University of Health and Welfare |
|---|
Principal Investigator |
TOTORIBE Naoko 九州保健福祉大学, 薬学部, 准教授 (70322576)
|
|---|
| Project Period (FY) |
2011-04-28 – 2013-03-31
|
| Keywords | 糖尿病 / バイパス血管 / 薬理学 |
|---|
| Research Abstract |
Rho/Rho kinase inhibitor significantly inhibited 5-HT-, NA-, AngII-, thorombin- and ADP-induced vasoconstrictions in the isolated human saphenous vein (SV). Furthermore, Rho/Rho kinase inhibitor significantly inhibited the enhanced vasocontractions to 5-HT, NA and AngII in diabetes mellitus (DM). These results indicate that the Rho-kinase inhibitor is a useful pharmacological tool to prevent vasospasm when the human SV from patients with DM were used as an arterial graft.
|
-
-
-
[Journal Article] The defective protein level of myosin light chain phosphatase (MLCP) in the isolated saphenous vein, as a vascular conduit in coronary artery bypass grafting (CABG), harvested from patients with diabetes mellitus (DM)2011
Author(s)
Matsuo Y, Kuwabara M, Tanaka-Totoribe N, Kanai T, Nakamura E, Gamoh S, Suzuki A, Asada Y, Hisa H, Yamamoto R
-
Journal Title
Biochem Biophys Res Commun
Volume: 412
Pages: 323-327
Peer Reviewed
-
-
-
