2012 Fiscal Year Final Research Report
The regulatory mechanism for the CERT-VAP interaction
| Project/Area Number |
23790118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
KUMAGAI Keigo 国立感染症研究所, 細胞化学部, 主任研究官 (40443105)
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| Co-Investigator(Renkei-kenkyūsha) |
HANADA Kentaro 国立感染症研究所, 細胞化学部, 部長 (30192701)
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| Project Period (FY) |
2011 – 2012
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| Keywords | セラミド / スフィンゴミエリン / CERT / VAP / FFATモチーフ / リン酸化 |
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| Research Abstract |
CERT is a cytosolic protein that transports ceramide from the endoplasmic reticulum to the Golgi apparatus. The CERT-mediated transport of ceramide is accelerated by interaction between CERT and ER-resident membrane protein, VAP-A, but a regulatory mechanism for the interaction has not been determined. In this study, we demonstrated that phosphorylation at certain residue of CERT strengthened the interaction between CERT and VAP-A to facilitate ER-to-Golgi ceramide trafficking by CERT.
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