2013 Fiscal Year Final Research Report
Development of highly sensitive fluorescent probes based on Quantum dot labeling
| Project/Area Number |
23790131
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
MATSUMOTO KENJI 九州大学, 先導物質化学研究所, 助教 (20531817)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 蛍光プローブ / 構造活性相関 / ボンクレキン酸 / キサンタチン |
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| Research Abstract |
Based on our developed total synthesis of BKA, we conducted the structure-activity relationship study, which revealed three carboxylic acid groups of BKA plays an important role in staurosporin-induced apoptosis inhibitory activity of HeLa cells. Next, we designed and synthesized simpler derivatives and the conformation-restricted derivatives and then found that these derivatives showed potent apoptosis inhibitory activity. Consequently, we successfully achieved the design and synthesis in more easily available potent novel apoptosis inhibitors, which would be useful for highly sensitive fluorescent probes. The efficient asymmetric synthesis of xanthatin based on the highly stereoselective conjugate allylation of the -butenolide was also achieved.
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Research Products
(27 results)
