2012 Fiscal Year Final Research Report
Development of methodology for site-specific RNA modification using the Reactive Oligonucleotides
| Project/Area Number |
23790146
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Sojo University |
|---|
Principal Investigator |
IMOTO Shuhei 崇城大学, 薬学部, 講師 (20447189)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | RNA 修飾 / 架橋反応 |
|---|
| Research Abstract |
RNA function is controlled by post-transcriptional modification. Therefore, there is increasing demand for methods of the site-specific modifications of RNA because of potential applications as biological tools and therapeutic methods. In this research, we are developing site-specific RNA modification tool using cross-linking forming oligonucleotide. We have found that the 6-vinylpurine newly designed in the current study serves well as a new nucleobase for increasing cross-link reactivity to target cytosine.
|
Research Products
(12 results)
