2012 Fiscal Year Final Research Report
Development of novel glycolipids that activates lymphocytes to induce anticancer activity
| Project/Area Number |
23790148
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
TASHIRO Takuya 独立行政法人理化学研究所, 免疫制御研究グループ, 研究員 (20339104)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | alpha-GalCer / CD1d / glycosphingolipid / IFN-gamma / Natural killer T cell |
|---|
| Research Abstract |
KRN7000, an alpha-galactosylated sphingolipid, stimulates natural killer T cells to induce antitumor activity. Based on the X-ray crystallographic analysis of CD1d/KRN7000/TCR, structure-activity relationship study on the 6-hydroxyl group of the galactose part of KRN7000 was performed. We synthesized several 6’’-carbamate analogs of KRN7000. It was found that these analogs were potent immunostimulants, and induced a large amount of IFN-gamma production in vivo (mouse).
|
Research Products
(15 results)
