2012 Fiscal Year Final Research Report
Molecular mechanism of gastric MALT lymphoma formation by infectionwith H. heilmannii
| Project/Area Number |
23790155
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ヘリコバクターハイルマニイ / 胃 MALT リンパ腫 / 細菌 |
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| Research Abstract |
In this study, we identified the molecular mechanism of gastric MALT lymphoma formation by infection with H. heilmannii. The results showed that the induced expression of several genes in CD86-dependent B cell activation pathway was observed. In this gastric mucosa, CTLA4, which is potent inhibitory receptor of CD80/86 dependent inflammation signal, is not induced regardless the chronic inflammation, resulting MALT lymphoma formation. In addition, we also demonstrated IL-10 is a crucial factor in this MALT lymphoma formation.
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Research Products
(7 results)
