2012 Fiscal Year Final Research Report
Characterization of bacterial iron transporter for the antioxidantability in Helicobacter pylori
| Project/Area Number |
23790156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 酸化ストレス / 抗酸化能 / 慢性感染 / 薬剤耐性 / 鉄トランスポーター |
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| Research Abstract |
Helicobacter pylori encodes a single iron-cofactored superoxide dismutase(SodB),which is regulated by the ferric uptake regulator (Fur). Ferrous ion (Fe^<2+>) is necessary for theactivation of SodB. The activity of SodB is an important determinant of the
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[Journal Article] Overexpression of miR-142-5p and miR-155in gastric mucosa-associated lymphoid tissue(MALT) lymphoma resistant to Helicobacterpylori eradication2012
Author(s)
Saito Y., Suzuki H., Tsugawa H., Imaeda H.,Matsuzaki J., Hirata K., Hosoe N.,Nakamura M., Mukai M., Saito H., Hibi T.
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Journal Title
PLoS One
Volume: 7
Pages: e47396
Peer Reviewed
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[Presentation] Specificamino acid mutation of p53 enhanced thestability of intracellular CagA by inhibitingautophagy induction2012
Author(s)
Tsugawa, H., Suzuki, H., Hatakeyama, M., Hirayama, T., Matsuzaki, J., Hirata, K.,Fukuhara, S., Okada, S., Hibi, T.
Organizer
Digestive Disease Week2012, Research forum
Place of Presentation
San Diego, USA
Year and Date
2012-05-21
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[Presentation] Essential role of FecA1,iron-uptake transporter, in Helicobacterpylori for host colonization andmetronidazole resistance2011
Author(s)
Tsugawa, H., Suzuki, H., Kanekawa, M.,Matsuzaki, J., Hirata, K., Okada, S., Fukuhara,S., Saito, Y., Hibi, T
Organizer
International Unionof Microbiological Societies (IUMS) 2011Congress
Place of Presentation
Sapporo, Japan
Year and Date
2011-09-07
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[Presentation] Essentialrole of FecA1, iron-uptake transporter, inHelicobacter pylori for antioxidant abilityassociated with survival within human stomach.2011
Author(s)
Tsugawa, H., Suzuki, H., Matsuzaki, J., Hirata,K., Okada, S., Fukuhara, S., Hibi, T.
Organizer
5th Biennial Meeting of Society forFree Radical Research-Asia
Place of Presentation
Kagoshima,Japan
Year and Date
2011-09-03
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[Presentation] The iron-uptake system for theantioxidant ability of Helicobacter pyloriregulated by Ferric uptake regulator (Fur).2011
Author(s)
Tsugawa, H., Suzuki, H., Hirata, K.,Matsuzaki, J., Okada, S., Fukuhara, S., Saito,Y., Hibi, T
Organizer
Digestive Disease Week 2011
Place of Presentation
Chicago, USA
Year and Date
2011-05-08
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[Presentation] pylori-derived oncoprotein,CagA is degraded by autophagy in human gastric epithelial cells2011
Author(s)
Tsugawa, H., Suzuki, H., Hatakeyama, M.,Matsuzaki, J., Hirata, K., Okada, S., Fukuhara,S., Hibi, T. H.
Organizer
Digestive DiseaseWeek 2011, Research forum
Place of Presentation
Chicago, USA
Year and Date
2011-05-07
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