2012 Fiscal Year Final Research Report
Molecular mechanisms underlying cytotoxic edema induced by methylmercury
| Project/Area Number |
23790157
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | メチル水銀 / 浮腫仮説 / 細胞性浮腫 / ポリオール経路 / アルドース還元酵素 / ソルビトール脱水素酵素 / p38 MAPK / Nrf2 |
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| Research Abstract |
Selective damage of the cerebrum in the patients with Minamata disease is attributed to methylmercury induced-cerebral edema. The purpose of the present study was to investigate the molecular mechanisms of cytotoxic edema caused by methylmercury. Aldose reductase dysfunction in polyol pathway is known to causes cytotoxic edema. We founded that methylmercury induced aldose reductase expressionvia p38 MAPK and transcription factor Nrf2 activation in cultured human brain microvascular pericytes. These resultssuggest the possibility that induction of aldose reductase expression might be one of the molecular mechanism underling cytotoxic edema induced by methylmercury.
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