2013 Fiscal Year Final Research Report
The regulation of energy metabolism by hepatic AhR
| Project/Area Number |
23790158
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
WADA Taira 日本大学, 薬学部, 助教 (20597398)
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| Project Period (FY) |
2011 – 2013
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| Keywords | AhR / メタボリックシンドローム / レプチン |
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| Research Abstract |
Recent studies suggest that AhR, known as dioxin receptor, is associated with glucose and lipid metabolism. Therefore, in this study, we examined the role of AhR on energy metabolism in the liver specific knockout AhR (L-AhR KO) mice. AhR LKO mice resulted in the elevation of insulin sensitivity, leading to the decrease in the ratio of body weigh gain. The reduction of food intake in AhR LKO mice resulted from the elevated serum leptin level and the increased leptin signaling in the hypothalamus. Deficiency of leptin abolished these effects in AhR LKO mice. Therefore, these results suggest that hepatic AhR is a novel factor in the regulation of energy metabolism through the modulation of leptin level.
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[Journal Article] Role of nuclear receptors in lipid dysfunction and obesity-related diseases2013
Author(s)
Swanson, H.I., Wada, T., Xie, W., Renga, B., Zampella, A., Distrutti, E., Fiorucci, S., Kong, B., Thomas, A.M., Guo, G.L., Narayanan, R., Yepuru, M., Dalton, J.T., and Chiang JY
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Journal Title
Drug Metab Dispos
Volume: Vol41
Pages: 1-11
Peer Reviewed
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[Journal Article] Estrogen sulfotransferase inhibits adipocyte differentiation2011
Author(s)
Wada, T., Ihunnah, C.A., Gao, J., Chai, X., Zeng, S., Philips, B.J., Rubin, J.P., Marra, K.G., and Xie, W. Mol
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Journal Title
Endocrinol
Volume: Vol25
Pages: 1612-1623
Peer Reviewed
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