2012 Fiscal Year Final Research Report
Molecular mechanisms of zinc-induced epigenetic changes in chromatinof MTF-1 target gene promoters
| Project/Area Number |
23790163
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | MTF-1 / 亜鉛 / メタロチオネイン |
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| Research Abstract |
Zinc is an essential micronutrient. It is critically important to control intracellular zinc concentrations tightly. In mammals, metallothionein (MT), a small metal-binding protein, plays important roles in zinc homeostasis. Mouse MT-I gene transcription is regulated by metal response element-binding transcription factor-l (MTF-l), which is recruited to the promoter by zinc. Previously we showed that alterations in the chromatin structure of the MT-I promoter associated with enhanced transcriptional activation. Here, we showed that chromatin remodeling factor Brm and Brg1 was not involved in the gene expression.
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