2012 Fiscal Year Final Research Report
Characterization of kidney specific organic anion transporter SLCO4C1
| Project/Area Number |
23790168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 薬物動態・代謝学 / 異物排泄 / トランスポーター |
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| Research Abstract |
Novel substrates for SLCO4C1 were searched and the contribution of SLCO4C1 to the renal uptake of the substrates in renal proximal tubular epithelial cells HK-2 cells was examined. As results, quinolinic acid and indole-3-acetate were found as novel substrates for SLCO4C1. SLCO4C1 mainly contributes to renal uptake of digoxin and ouabain in HK-2 cells.
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