2012 Fiscal Year Final Research Report
Involvement of intracellular vesicular trafficking in toxicity of anticancer drugs
| Project/Area Number |
23790171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 制がん剤 / 細胞内小胞輸送経路 / エンドサイトーシス |
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| Research Abstract |
We examined the relationship between intracellular transport pathways and adriamycin toxicity, and found that defect of genes for endoplasmic reticulum (ER)-to-golgi transport enhanced adriamycin toxicity. We also found that disruption of Erv14, one of the cargo receptors involved in ER-to-golgi transport, conferred hypersensitivity to adriamycin. Our results suggest that Erv14 dependent ER-to-golgi transport system plays a major role in the defense mechanism against toxicity of adriamycin.
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