2013 Fiscal Year Final Research Report
The role of phosphorylation status of radixin on the localization of billiary transporters
| Project/Area Number |
23790172
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
SEKINE Shuichi 千葉大学, 薬学研究科(研究院), 助教 (70401007)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 胆汁うっ滞 / トランスポーター / 胆汁酸 |
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| Research Abstract |
In this study, we examined localization of biliary transporters and physiological liver failure in chronic hepatitis by using human liver slices. We could determine the new binding partners (AnexinA2 etc) of biliary transporters by using two-dimensional fluorescence differential analysis with Ethan DIGE. And we could characterize AnexinA2 which negatively regulates the canalicular membrane localization of Mrp2 and Bsep. Moreover, chlestatic drugs(CyclopsorinA and Glibenclamide), including inhibitors of Bsep, one of biliary transporter, shows hepatotoxicity in the presence of the concentrated bile acids mixtureby using human sandwich cultured hepatocytes.
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Research Products
(45 results)
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[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込み機構の関与2012
Author(s)
伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
Organizer
第132年会日本薬学会
Place of Presentation
札幌
Year and Date
20120328-31
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[Presentation] C型肝炎の病態悪化に対するミトコンドリア鉄蓄積と鉄取り込み機構の関与2012
Author(s)
伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
Organizer
肝病態生理研究会
Place of Presentation
金沢
Year and Date
2012-06-06
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[Presentation] C型肝炎ウイルスコア蛋白質により誘発されるミトコンドリア障害に対する鉄蓄積の関与2011
Author(s)
伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
Organizer
第131年会日本薬学会
Place of Presentation
静岡
Year and Date
20110328-31
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