2013 Fiscal Year Final Research Report
The mechanisms of the variability in the intestinal absorption of nucleoside drugs
| Project/Area Number |
23790176
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
ISHIDA Kazuya 富山大学, 大学院医学薬学研究部(薬学), 助教 (90550509)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 薬物動態 / トランスポーター / 臨床試験 |
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| Research Abstract |
The findings in the present study indicate that the variable bioavailability (F) of mizoribine is one of the factors for the interindividual pharmacokinetic variability of the drug in healthy volunteers and adult and pediatric recipients of renal transplantation, and that the genetic polymorphism of concentrative nucleoside transporter (CNT) 1 is partly involved in the variable F of mizoribine. In addition, the membrane transport of mizoribine in intestinal epithelial cells is mediated by CNT1, CNT2, equilibrative nucleoside transporters (ENTs), and unidentified efflux transporter(s).
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