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2013 Fiscal Year Final Research Report

Investigation of relationship between the pharmacokinetics of and clinical responses to prochlorperazine in patients receiving opioids

Research Project

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Project/Area Number 23790181
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

NAITO Takafumi  浜松医科大学, 医学部附属病院, 副薬剤部長 (80422749)

Research Collaborator TASHIRO Masaki  浜松医科大学, 医学部附属病院, 薬剤師
Project Period (FY) 2011 – 2013
Keywordsプロクロルペラジン / オピオイド / 薬物動態 / 有害作用 / ドパミンD2受容体 / オピオイドμ1受容体 / 遺伝子多型 / 緩和医療
Research Abstract

Prochlorperazine has a high potency antiemetic effect based on inhibiting dopamine D2 receptor and is commonly used for the treatment of opioid-induced nausea and vomiting in cancer patients. Clinical responses to prochlorperazine vary in patients receiving opioids. Opioids bind to opioid receptor mu1 on the hypothalamus and subsequently cause the blockade of dopaminergic pathways. This study evaluated the interindividual variation in pharmacokinetics of and clinical responses to prochlorperazine based on non-genetic and genetic factors in patients receiving opioids.

  • Research Products

    (4 results)

All 2014 2012 2011

All Journal Article (2 results) Presentation (2 results)

  • [Journal Article] Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients2014

    • Author(s)
      Tashiro M, Naito T, Ohnishi K, Kagawa Y, Kawakami J
    • Journal Title

      Clin Chim Acta

      Volume: 429 Pages: 175-180

    • DOI

      10.1016/j.cca.2013.12.011

  • [Journal Article] Simultaneous determination of prochlorperazine and its metabolites in human plasma using isocratic liquid chromatography tandem mass spectrometry2012

    • Author(s)
      Tashiro M, Naito T, Kagawa Y, Kawakami J
    • Journal Title

      Biomed Chromatogr

      Volume: 26 Pages: 754-760

    • DOI

      10.1002/bmc.1725

  • [Presentation] がん患者におけるプロクロルペラジンの制吐作用および有害作用に及ぼすDRD2の遺伝子変異の影響2011

    • Author(s)
      田代将貴,内藤隆文,賀川義之,川上純一
    • Organizer
      第21回日本医療薬学会年会
    • Place of Presentation
      神戸
    • Year and Date
      20111000
  • [Presentation] Relationships between prochlorperazine pharmacokinetics and Its clinical responses based on DRD2 gene polymorphisms in cancer patients receiving opioid analgesics2011

    • Author(s)
      Tashiro M, Naito T, Takashina Y, Kagawa Y, Kawakami J
    • Organizer
      10th Congress of the European Association for Clinical Pharmacology and Therapeutics
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      20110600

URL: 

Published: 2015-06-25  

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