2012 Fiscal Year Final Research Report
Alteration of renal drug transporters during growth and its effects on the pharmacokinetics
| Project/Area Number |
23790182
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 薬学 / 医療系薬学 |
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| Research Abstract |
The purpose of this study was to elucidate the developmental changes in the expression of transporters and their effects on the renal excretion of drugs. The protein expression of the transporters were very low at postnatal day 0 and gradually increased with age. On the other hand, the tubular secretion of PSP was significantly lower in postnatal day 14 rats than adult rats. These results indicate that age-dependent changes in organic anion transporter expression affect the tubular secretion of anionic drugs in pediatric patients.
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