2012 Fiscal Year Final Research Report
Post-translational Regulation of Disease-associated ABC Transporters by Derlin1 and HRD1
| Project/Area Number |
23790188
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
SHUTO Tsuyoshi 熊本大学, 大学院・生命科学研究部, 講師 (80333524)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | ABC トランスポーター / 翻訳後調節 / ABCG5/8 / BCRP / N 型糖鎖 |
|---|
| Research Abstract |
In this study, we sought to determine molecular mechanisms responsible for post-translational regulation of BCRP and ABCG5/8, disease-associated ABC transporter family proteins. Here, we showed that Derlin-1 is a negative regulator for both glycosylated and non-glycosylated BCRP expression. Moreover, we demonstrated HRD1 as a regulator of post-translational N-glycosylation of ABCG8 that affects protein stability. Overall, we clearly indicate the molecular basis of Derlin-1- and HRD1-dependent negative regulation of BCRP and ABCG5/ABCG8.
|
Research Products
(18 results)
-
[Journal Article] STT3B-Dependent Posttranslational N-Glycosylation as a Surveillance System for Secretory Protein.2012
Author(s)
Sato T, Sako Y, Sho M, Momohara M,Suico MA, Shuto T, Nishitoh H, OkiyonedaT, Kokame K, Kaneko M, Taura M, Miyata M,Chosa K,Koga T, Morino-Koga S, Wada I, KaiH
-
Journal Title
Mol Cell.
Volume: 47(1)
Pages: 99-110
DOI
Peer Reviewed
-
-
-
-
-
[Journal Article] Posttranslational negative regulation ofglycosylated and non-glycosylated BCRPexpression by Derlin-12011
Author(s)
Sugiyama, T., T. Shuto, S. Suzuki, T.Sato, T. Koga, M.A. Suico, H. Kusuhara, Y.Sugiyama, D.M. Cyr, and H. Kai
-
Journal Title
Biochem Biophys Res Commun
Volume: 404
Pages: 853-858
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
