2012 Fiscal Year Final Research Report
Exploration of the drug for atherosclerosis which related to the proliferation of smooth muscle cells-induced rupture of vascular redox homeostasis
| Project/Area Number |
23790190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | EC-SOD / MEK/ERK / フラボノイド |
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| Research Abstract |
We investigated the regulation of EC-SOD during FCS-induced VSMCs proliferation to explore the drug for atherosclerosis. We confirmed that the reduction of EC-SOD during FCS-induced cells proliferation through MEK/ERK-derived signaling. Further, pretreatment with flavonoids such as luteolin and chrysoeriol significantly suppressed FCS-triggered EC-SOD reduction. Overall, we suggested that the regulation of EC-SOD might lead to improve vascular diseases.
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