2012 Fiscal Year Final Research Report
Basic research for development of new drugs based on the regulationof ABC transporters activity and expression
| Project/Area Number |
23790196
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 薬物動態 / 代謝学 / ABC 輸送体 |
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| Research Abstract |
P-glycoprotein (P-gp) is a member of the ABC transporters and transports several anticancer drugs. Overexpression of P-gp in cancer cells contributes resistance to the anticancer agents. This study aimed to clarify the mechanisms o
(1) P-gp wasrecognized by SCFFBX15, ubiquitinated by Ube2r1/Cdc34/Ubc3 and then degraded by the proteasome;
(2) expression of the protein dephosphorylation complex PP5/PPP2R3Clowered P-gp expression.
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Research Products
(9 results)
