2013 Fiscal Year Final Research Report
Multifaceted antioxidant evaluation of medicine and functional food for the lifestyle-related disease
| Project/Area Number |
23790211
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 生活習慣病 / 抗酸化作用 / キトサン / アルブミン / 酸化ストレス |
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| Research Abstract |
We investigated the effect of chitosan on oxidative stress and related biochemical properties in lifestyle diseases. In metabolic syndrome patients or model rats, chitosan has a high antioxidant activity as well as the ability to exert antilipidemic effects. Furthermore, in chronic renal failure (CRF) patients or model rats, chitosan has a high antioxidant activity as well as the ability to exert reno-protective effects. From these results, we hypothesize that chitosan reduces the levels of lipids and/or uremic toxins that induce the production of reactive oxygen species in the intestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in the metabolic syndrome or CRF. Thus, the pleiotropic effects of chitosan might lead to the development of effective new methods for the treatment of such diseases and for reducing oxidative stress associated with lifestyle diseases such as metabolic syndrome or CRF.
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Research Products
(30 results)
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[Journal Article] Differential effects of methoxy group on the interaction of curcuminoids with two major ligand binding sites of human serum albumin2014
Author(s)
Sato H, Chuang VT, Yamasaki K, Yamaotsu N, Watanabe H, Nagumo K, Anraku M, Kadowaki D, Ishima Y, Hirono S, Otagiri M, Maruyama T
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Journal Title
PLoS One
Volume: 9
Pages: e87919
DOI
Peer Reviewed
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[Journal Article] Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases2014
Author(s)
Nagumo K, Tanaka M, Chuang VT, Setoyama H, Watanabe H, Yamada N, Kubota K, Tanaka M, Matsushita K, Yoshida A, Jinnouchi H, Anraku M, Kadowaki D, Ishima Y, Sasaki Y, Otagiri M, Maruyama T
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Journal Title
PLoS One
Volume: 8
Pages: e85216
DOI
Peer Reviewed
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[Journal Article] Antioxidant properties of high molecular weight dietary chitosan in vitro and in vivo2011
Author(s)
Anraku M, Fujii T, Kondo Y, Kojima E, Hata T, Tabuchi N, Tsuchiya D, Goromaru T, Tsutsumi H, Kadowaki D, Maruyama T, Otagiri M, Tomida H
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Journal Title
Carbohydr Polym
Volume: 83
Pages: 501-505
DOI
Peer Reviewed
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[Presentation] 透析患者の酸化ストレス及び高リン血症に対するキトサンの有用性評価2013
Author(s)
平賀 歩,安楽 誠,田中 元子,南雲 恒平,渡邊 博志,庵原 大輔,上釜 兼人,平山 文俊,丸山 徹,小田切 優樹
Organizer
第30回日本薬学会九州支部大会
Place of Presentation
長崎国際大学,佐世保
Year and Date
20131207-08
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[Presentation] 透析患者におけるキトサンの抗酸化及び腎保護効果の検討2013
Author(s)
平賀 歩,安楽 誠,田中 元子,南雲 恒平,渡邊 博志,庵原 大輔,上釜 兼人,平山 文俊,丸山 徹,小田切 優樹
Organizer
日本薬剤学会第28年会
Place of Presentation
ウインク愛知,愛知
Year and Date
20130523-25
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