Functional analysis of Jmjd5, a candidate cancer-related geneidentified by retroviral insertional mutagenesis

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790220
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Kanazawa University
• Principal Investigator: ISHIMURA Akihiko 金沢大学, がん進展制御研究所, 助教 (80375261)
• Project Period (FY): 2011 – 2012
• Keywords: 遺伝子発現 / 発生・分化 / 細胞増殖 / 癌

Research Abstract

Our retroviral insertional mutagenesis in mice showed frequent identification of JmjC family genes as novel candidates cancer-related genes. Jmjd5, one of the family genes, was also a target for the retrovirus, and we generated Jmjd5-deficientmice (Jmjd5△囗△) to investigate the physiological role of Jmjd5. We showed that Jmjd5 was involved in embryonic cell proliferation by fine-tuning the expression of p21 (Ishimura et al., Development 2012).

Research Products

• [Journal Article] Jmjd5. an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression (2012)
  • Author(s): Ishimura A, Minehata K, Terashima M, Kondoh G, Hara T and Suzuki T
  • Journal Title: Development Volume: 139 Pages: 749-759
  • DOI: DOI:10.1242/dev.074138
  • Peer Reviewed
• [Journal Article] PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells (2011)
  • Author(s): Yoshida M, Ishimra A, Terashima M, Enkhbaatar Z, Nozaki N, Satou K and Suzuki T
  • Journal Title: Biochemical J Volume: 437 Pages: 555-564
  • DOI: DOI:10.1042/BJ20110343
  • Peer Reviewed
• [Presentation] Jmjd5, a JmjC domain containing protein, modulates embryonic cell proliferation through the regulation of p53-target genes expression (2013)
  • Author(s): Ishimura A
  • Organizer: 3rdInternational Symposium on Carcinogenic Spiral and International Symposium in Tumor Biology in Kanazawa
  • Place of Presentation: 金沢東急エクセルホテル(石川県)
  • Year and Date: 2013-01-25
• [Presentation] Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of p53-target genes expression (2012)
  • Author(s): Ishimura A, Minehata K, Terashima M, Kondoh G, Hara T and Suzuki T
  • Organizer: 第35回分子生物学学会年会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2012-12-13
• [Presentation] Jmjd5, which is identified by retroviral insertional mutagenesis, regulates embryonic cell proliferation through the epigenetic control of Cdkn1a (2011)
  • Author(s): Ishimura A, Minehata K, Terashima M, Kondoh G, Hara T and Suzuki T
  • Organizer: 第34回分子生物学学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-13
• [Presentation] Jmjd5, a candidate cancere-related gene identified by retroviral insertional mutagenesis, regulates the expression of Cdkn1a and modulates embryonic cell proliferation (2011)
  • Author(s): Ishimura A, Minehata K, Terashima M, Hara T and Suzuki T
  • Organizer: International Symposium on Tumor Biology in Kanazawa and the 11thSpring Symposium of the Molecular Biology Society of Japan
  • Place of Presentation: 石川県立音楽堂(石川県)
  • Year and Date: 2011-05-25