2012 Fiscal Year Final Research Report
Involvement of SUMOylation in pathogenesis of neural diseases
Project/Area Number |
23790224
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
|
Keywords | SUMO 化 / アルツハイマー病 / 小胞体ストレス / 細胞死 / 神経変性疾患 |
Research Abstract |
In this project, effects of SUMOylation on neural system has been investigated to elucidate the involvement of it in the pathogenesis of neural and neurodegenerative diseases. As results, SUMOylation should play important roles to maintain synaptic functions and protective function against the neural death pathway observed in neurodegenerative diseases, especially ER stress pathway. The data show that SUMOylation regulates CHOP expression, one of inducers of apoptosis. These results suggest that neural SUMOylation should work protectively against ER stress and regulates the synapse function in neural and neurodegenerative disease.
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Research Products
(26 results)