2012 Fiscal Year Final Research Report
Functional Analysis of a novel gene, Cue110, involved in retrotransposon suppression
| Project/Area Number |
23790225
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生殖細胞 / レトロトランスポゾン / piRNA / ノックアウトマウス |
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| Research Abstract |
In mouse germ cells of prenatal testis, there is a mechanism to protect own genome, a plan of the living body, from mutagens called as retrotransposons, which express from own genome and damage it. In the current study, I revealed that a product encoded by a Cue110 gene associates with other related gene products, and plays important role for the defencing mechanism.
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