2012 Fiscal Year Final Research Report
The analysis of urinary tract formation; a new approach focused on the developmental role of cloaca during embryogenesis
| Project/Area Number |
23790228
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Ehime University |
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Principal Investigator |
HARAGUCHI Ryuma 愛媛大学, 大学院・医学系研究科, 講師 (00423690)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAZAWA Sohei 愛媛大学, 大学院・医学系研究科, 教授 (90186239)
KITAZAWA Riko 愛媛大学, 大学院・医学系研究科, 准教授 (00273780)
YAMADA Gen 和歌山県立医科大学, 教授 (80174712)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 泌尿生殖器 |
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| Research Abstract |
Congenital diseases of the urinary tract are frequently observed in infants. Such diseases present a number of developmental anomalies such as hydroureter and hydronephrosis. Although some genetically-modified mouse models of growth factor signaling genes reproduce urinary phenotypes, the pathogenic mechanisms remain obscure. Previous studies suggest that a portion of the cells in the external genitalia and bladder are derived from peri-cloacal mesenchymal cells that receive Hedgehog (Hh) signaling in the early developmental stages. We hypothesized that defects insuch progenitor cells, which give rise to urinary tract tissues, may be a cause of such diseases. Our study identified the essential embryonic stages for the pathogenesis of urinary tract phenotypes. These results suggested that Hh-responsive mesenchymal Bmp signaling maintains the population of peri-cloacal mesenchyme cells, which is essential for the development of the ureter and the upper urinary tract.
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Research Products
(19 results)
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[Journal Article] Reduced BMP Signaling Results in Hindlimb Fusion with Lethal Pelvic/Urogenital Organ Aplasia: A New Mouse Model of Sirenomelia.2012
Author(s)
Suzuki K, Adachi Y, Numata T, Nakada S, Yanagita M, Nakagata N, Evans M. S, Daniel G, Economides A, Haraguchi R, Moon M. A, Yamada G
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Journal Title
PLoS One
Volume: 7(9)
Pages: e43453
Peer Reviewed
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[Journal Article] The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia2011
Author(s)
Miyagawa S, Matsumaru D, Murashima A, Omori A, Satoh Y, Haraguchi R, Motoyama J, Iguchi T, Nakagata N, Hui CC, Yamada G
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Journal Title
Endocrinology
Volume: 152(7)
Pages: 2894-903
Peer Reviewed
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