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2012 Fiscal Year Final Research Report

The analysis of urinary tract formation; a new approach focused on the developmental role of cloaca during embryogenesis

Research Project

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Project/Area Number 23790228
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including Histology/Embryology)
Research InstitutionEhime University

Principal Investigator

HARAGUCHI Ryuma  愛媛大学, 大学院・医学系研究科, 講師 (00423690)

Co-Investigator(Renkei-kenkyūsha) KITAZAWA Sohei  愛媛大学, 大学院・医学系研究科, 教授 (90186239)
KITAZAWA Riko  愛媛大学, 大学院・医学系研究科, 准教授 (00273780)
YAMADA Gen  和歌山県立医科大学, 教授 (80174712)
Project Period (FY) 2011 – 2012
Keywords泌尿生殖器
Research Abstract

Congenital diseases of the urinary tract are frequently observed in infants. Such diseases present a number of developmental anomalies such as hydroureter and hydronephrosis. Although some genetically-modified mouse models of growth factor signaling genes reproduce urinary phenotypes, the pathogenic mechanisms remain obscure. Previous studies suggest that a portion of the cells in the external genitalia and bladder are derived from peri-cloacal mesenchymal cells that receive Hedgehog (Hh) signaling in the early developmental stages. We hypothesized that defects insuch progenitor cells, which give rise to urinary tract tissues, may be a cause of such diseases. Our study identified the essential embryonic stages for the pathogenesis of urinary tract phenotypes. These results suggested that Hh-responsive mesenchymal Bmp signaling maintains the population of peri-cloacal mesenchyme cells, which is essential for the development of the ureter and the upper urinary tract.

  • Research Products

    (19 results)

All 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Intestinal inflammatory pseudotumor caused by taeniasis: calcareous corpuscles as a diagnostic clue2013

    • Author(s)
      Sann Sanda Khin, Riko Kitazawa, Kyaw Htet, Hla Min Htike, Than Than Yee, Myint Aung, Ryuma Haraguchi and Sohei Kitazawa
    • Journal Title

      Pathology International

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Pulmonary hypertension associated with diffuse deposition of pentosidine in pulmonary arterioles2013

    • Author(s)
      Komoda Munenori, Riko Kitazawa, Kenji Makita, Keisuke Yoshida, Miyuki Takeji, Yoshiko Soga, Mie Kurata, Ryuma Haraguchi, Sohei Kitazawa
    • Journal Title

      Diabetes Research and Clinical Practice

    • Peer Reviewed
  • [Journal Article] Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression2013

    • Author(s)
      Natsumi Kuwahara, Riko Kitazawa, Koto Fujiishi, Yusa Nagai, Ryuma Haraguchi, Sohei Kitazawa
    • Journal Title

      World Journal of Gastroenterology

      Volume: 19(8) Pages: 1314-1317

    • Peer Reviewed
  • [Journal Article] Efficient genetic analysis of microdissected samples by agarose-bead method: Alterations of β-catenin gene in fundic gland polyp and heterotopic gastric mucosa of duodenum2013

    • Author(s)
      Miku Nakagawa, Riko Kitazawa, Natsumi Kuwahara, Keisuke Yoshida, Ryuma Haraguchi, Sohei Kitazawa
    • Journal Title

      Acta Histochem Cytochem

      Volume: 46(1) Pages: 19-24

    • Peer Reviewed
  • [Journal Article] Cdx2 expression and its promoter methylation during metaplasia-dysplasia-carcinoma sequence in Barrett's esophagus2013

    • Author(s)
      Makita K, Kitazawa R, Fujiishi K, Nakagawa M, Haraguchi R, Kitazawa S
    • Journal Title

      World Journal of Gastroenterology

      Volume: 19(4) Pages: 536-41

    • Peer Reviewed
  • [Journal Article] Reduced BMP Signaling Results in Hindlimb Fusion with Lethal Pelvic/Urogenital Organ Aplasia: A New Mouse Model of Sirenomelia.2012

    • Author(s)
      Suzuki K, Adachi Y, Numata T, Nakada S, Yanagita M, Nakagata N, Evans M. S, Daniel G, Economides A, Haraguchi R, Moon M. A, Yamada G
    • Journal Title

      PLoS One

      Volume: 7(9) Pages: e43453

    • Peer Reviewed
  • [Journal Article] The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis2012

    • Author(s)
      Haraguchi R, Matsumaru D, Nakagata N, Miyagawa S, Suzuki K, Kitazawa S, Yamada G
    • Journal Title

      PLoS One

      Volume: 7(7) Pages: e42245

    • Peer Reviewed
  • [Journal Article] Cutaneous verruciform xanthoma on the scrotum with MCP-1 immunohistochemical study: a case report2012

    • Author(s)
      Ito C, Kitazawa R, Makita K, Watanabe T, Toda A, Haraguchi R, Tanaka S and Kitazawa S
    • Journal Title

      Journal of Medical Case Reports

    • Peer Reviewed
  • [Journal Article] Multiple-system atrophy in long-term professional painter: a case report2012

    • Author(s)
      Nagai Y, Kitazawa R, Nakagawa M, Komoda M, Kondo T, Haraguchi R and Kitazawa S
    • Journal Title

      Case Reports in Pathology

      Volume: volume2012 Pages: 5

    • Peer Reviewed
  • [Journal Article] Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation2011

    • Author(s)
      Matsumaru D, Haraguchi R, Miyagawa S, Motoyama J, Nakagata N, Meijlink F, Yamada G
    • Journal Title

      PLoS One

      Volume: 6(1) Pages: e16260

    • Peer Reviewed
  • [Journal Article] The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia2011

    • Author(s)
      Miyagawa S, Matsumaru D, Murashima A, Omori A, Satoh Y, Haraguchi R, Motoyama J, Iguchi T, Nakagata N, Hui CC, Yamada G
    • Journal Title

      Endocrinology

      Volume: 152(7) Pages: 2894-903

    • Peer Reviewed
  • [Journal Article] Epigenetic Alteration by DNA Promoter Hypermethylation of Genes Related to Transforming Growth Factor- β (TGF- β) Signaling in Cancer.2011

    • Author(s)
      Khin SS, Kitazawa R, Kondo T, Idei Y, Fujimoto M, Haraguchi R, Mori K, Kitazawa S
    • Journal Title

      Cancers

      Volume: 3(1) Pages: 982-993

    • Peer Reviewed
  • [Journal Article] Identification and analysis of function of a novel splicing variant of mouse receptor activator of NF-κB2011

    • Author(s)
      Mukai S, Kitazawa R, Ishii J, Kondo T, Hakozaki A, Horiuchi K, Haraguch R, Mori K, Kitazawa S
    • Journal Title

      Mol Cell Biochem

      Volume: 350(1-2) Pages: 29-38

    • Peer Reviewed
  • [Presentation] Spatio-temporal expression of Tbx18 during endochondral bone formation2012

    • Author(s)
      Ryuma Haraguchi, Riko Kitazawa, Sohei Kitazawa
    • Organizer
      第14回国際組織細胞化学会総会・学術集会
    • Year and Date
      20120826-29
  • [Presentation] 骨形成過程における Tbx18 遺伝子の役割2012

    • Author(s)
      原口竜摩、北澤理子、北澤荘平
    • Organizer
      第30回日本骨代謝学会総会・学術集会
    • Year and Date
      20120719-21
  • [Presentation] 胎児期骨形成過程におけるTbx18 遺伝子の役割2012

    • Author(s)
      原口竜摩、北澤理子、北澤荘平
    • Organizer
      第101回日本病理学会総会・学術集会
    • Year and Date
      20120426-28
  • [Presentation] 骨形成/骨成熟過程における Tbx18 遺伝子の役割2011

    • Author(s)
      原口竜摩、北澤理子、北澤荘平
    • Organizer
      第52回日本組織細胞化学会総会・学術集会
    • Year and Date
      20110924-25
  • [Presentation] 新規遺伝子改変マウスを用いた平滑筋組織の機能破綻に起因する腎尿路疾患についての解析2011

    • Author(s)
      原口竜摩、松丸大輔、杉田敦郎、木藤克己、阿部康人、北澤理子、山田源、北澤荘平
    • Organizer
      第100回日本病理学会総会・学術集会
    • Year and Date
      20110428-30
  • [Remarks]

    • URL

      http://www.m.ehime-u.ac.jp/school/pathology1/index.html

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Published: 2014-08-29   Modified: 2014-10-09  

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