2012 Fiscal Year Final Research Report
Roles of ununiform cellular signaling during cardiac morphogenesis
| Project/Area Number |
23790232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Nara Medical University |
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Principal Investigator |
SAKABE Masahide 奈良県立医科大学, 循環器システム医科学, 助教 (00525983)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞分化 / 組織形成 / 心臓発生学 / 発生遺伝学 |
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| Research Abstract |
Generation of endocardial cushion in the atrioventricular canal (AVC) and outflow tract (OFT) of developing heart is essential for subsequent chamber septation and valvulogenesis. During endocardial cushion formation, only a fraction of endothelialcells lining AVC and OFT are activated and undergo endothelial-mesenchymal transformation (EMT). In this study, we demonstrated that Notch signaling might play important roles in such differential cell-fate decision through its selective and ununiform activation in endothelial cells during EMT.
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