Novel immunosuppressive protocol in whichdepleting donor dendritic-cells by anti-MHC-II antibodies.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23790235
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Dokkyo Medical University
• Principal Investigator: UETA Hisashi 獨協医科大学, 医学部, 准教授 (10364556)
• Project Period (FY): 2012 – 2013
• Keywords: 免疫組織学 / 樹状細胞 / cell trafficking / 移植免疫 / 免疫抑制 / 抗体 / MHC-II / ラット

Research Abstract

We identified 2 types of immunogeneic dendritic-cells in rat liver and developed a novel immunosuppressive protocol by depleting them using antibody against MHC-II.

Research Products

• [Journal Article] Two immunogenic passenger dendritic-cell subsets in the rat liver have distinct trafficking patterns and radiosensitivities (2012)
  • Author(s): Yu B*, Ueta H*, Matsuno K
  • Journal Title: Hepatology Volume: 56(4) Pages: 1532-45
  • DOI: DOI:10.1002/hep.25795
• [Presentation] Two distinct immunogenic passenger cDC subsets in rat liver graft rejection (2012)
  • Author(s): Ueta H, Kitazawa Y, Sawanobori Y, Matsuno K
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 20121205-07
• [Presentation] Trafficking of two immunogenic conventional DC subsets in the liver (2012)
  • Author(s): Ueta H, Yu B, Kitazawa Y, Sawanobori Y, Matsuno K
  • Organizer: The 12th International Symposium on Dendritic Cells
  • Place of Presentation: Daegu, Korea
  • Year and Date: 20121007-11
• [Presentation] Two immunogenic passenger dendritic-cell subsets in the rat liver have distinct trafficking patterns and radiosensitivities (2012)
  • Author(s): 上田祐司, 松野健二郎, 沢登祥史, 北沢祐 介 , 余 斌
  • Organizer: 第117回 日本解剖学会全国学術集会
  • Place of Presentation: 甲府市
  • Year and Date: 20120326-28
• [Remarks]
  • URL: http://macro.dokkyomed.ac.jp/index.html