2012 Fiscal Year Final Research Report
(Pro)renin receptor in cerebral, cardiac and renal diseases
| Project/Area Number |
23790242
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Tohoku University |
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Principal Investigator |
HIROSE Takuo 東北大学, 大学院・医学系研究科, 非常勤講師 (20599302)
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| Research Collaborator |
IMAI Yutaka 東北大学, 大学院・薬学研究科, 教授 (40133946)
TOTSUNE Kazuhito 東北大学, 大学院・薬学研究科, 客員教授 (10217515)
TAKAHASHI Kazuhiro 東北大学, 大学院・医学系研究科, 教授 (80241628)
MORI Takefumi 東北大学, 大学院・医学系研究科, 准教授 (40375001)
MORI Nobuyoshi 東北大学, 大学院・医学系研究科, 助教 (50463790)
GENEVIEVE NGUYEN College de France, Center for Interdisciplinary Research in Biology, Director
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| Project Period (FY) |
2011 – 2012
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| Keywords | (プロ)レニン受容体 / レニン・アンジオテンシン系 / 生理活性物質 / 発現・制御 / 腎障害 |
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| Research Abstract |
The aim of this study is to clarify the roles of (pro)renin receptor in cerebral, cardiac and renal diseases. We have demonstrated that expression of (pro)renin receptor protein in mouse kidney is increased after dehydration or high salt diet. We also showed that (pro)renin receptor regulates vesicular pH. Plasma soluble (pro)renin receptor concentration is increased in the patients of congestive heart failure and chronic renalfailure. These observations suggest that (pro)renin receptor has crucial roles in organ homeostasis and cerebral, cardiac and renal diseases.
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[Journal Article] Plasma renin activity and the aldosterone-to-renin ratio are associated with the development of chronic kidney disease: the Ohasama study2012
Author(s)
Terata S,Kikuya M,Satoh M,Ohkubo T, Hashimoto T,Hara A,Hirose T, Obara T, Metoki H,Inoue R,Asayama K,Kanno A, Totsune K,Hoshi H,Satoh H,Sato H,Imai Y.
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Journal Title
J Hypertens
Volume: 25
Pages: 1632-1638
DOI
Peer Reviewed
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[Journal Article] Association of (pro)renin receptor gene polymorphism with lacnur infarction and left ventricular hypertrophy in Japanese women: The Ohasama Study2011
Author(s)
Satoh M,Kikuya M,Ohkubo T,Mori T,Metoki H,Hara A,Utsugi MT,Hashimoto T,Asayama K,Kondo T,Kamide K,Katsuya T, Ogihara T,Izumi S,Rakugi H,Takahashi K, Imai Y.
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Journal Title
Hypertens Res
Volume: 34
Pages: 530-535
DOI
Peer Reviewed
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[Journal Article] Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population: the Ohasama Study2011
Author(s)
Satoh M,Kikuya M,Ohkubo T,Mori T,Metoki H,Hashimoto T,Hara A,Utsugi MT,Hirose T,Obara T,Inoue R,Asayama K,Kanno A,Totsune K,Hoshi H,Satoh H,Imai Y.
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Journal Title
J Hypertens
Volume: 29
Pages: 1940-1947
DOI
Peer Reviewed
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[Journal Article] Association of (pro)renin receptor gene polymorphism with lacnur infarction and left ventricular hypertrophy in Japanese women2011
Author(s)
Hirose T,Hashimoto M,Totsune K,Metoki H,Hara A,Satoh M,Kikuya M,Ohkubo T,Asayama K,Kondo T,Kamide K,Katsuya T,Ogihara T,Izumi S,Rakugi H,Takahashi K,Imai Y.
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Journal Title
The Ohasama Study.Hypertens Res.
Volume: 34
Pages: 530-535
DOI
Peer Reviewed
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