2013 Fiscal Year Final Research Report
Quantitative analysis of the vestibulo-cardiovascular reflex in orthostatic hypotension
| Project/Area Number |
23790246
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Gifu University |
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Principal Investigator |
ABE Chikara 岐阜大学, 医学(系)研究科(研究院), 准教授 (10585235)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 圧受容器反射 / 起立性低血圧 / 飲水－昇圧反射 / 食塩感受性高血圧 / 不整脈 / 期外収縮 / ミクログリア / 機械受容器 |
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| Research Abstract |
The purpose of the present study is 1) clarification of the interaction between vestibular system and arterial baroreflex during orthostatic hypotension, 2) clarification of the mechanism in water drinking-induced pressor response, and 3) examination of the effectiveness in water drinking-induced pressor response in aged people. In the animal experiment, denervation of both arterial baroreflex and vestibular input induced sever hypotension during rearing up. However, the arterial pressure was increased by about 60 mmHg during rearing up with water drinking, and this pressor response was due to sympathoexcitation. Water drinking-induced pressor response was observed in aged people although its size was smaller, indicating that the orthostatic hypotension might be prevented by water drinking.
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Research Products
(14 results)
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[Journal Article] Arterial pressure oscillation and muscle sympathetic nerve activity after 20 days of head-down bed rest2013
Author(s)
Tanaka K, Nishimura N, Sato M, Kanikowska D, Shimizu Y, Inukai Y, Abe C, Iwata C, Morita H, Iwase S, Sugenoya J
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Journal Title
Auton Neurosc
Volume: Oct;177(2)
Pages: 266-270
DOI
Peer Reviewed
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