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2013 Fiscal Year Final Research Report

Role of If channel remodeling in atrial fibrillation appearance in diabets

Research Project

  • PDF
Project/Area Number 23790249
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionOita University

Principal Investigator

TETSUJI SHINOHARA  大分大学, 医学部, 助教 (60457629)

Project Period (FY) 2011 – 2013
Keywords洞房結節 / 心房細動 / 糖尿病 / 洞不全症候群
Research Abstract

Both the membrane clock and the Ca2+ clock are important in the initiation of the heart beat, and malfunction of these two clocks leads to sinoatrial node (SAN) dysfunction. SAN function and arrhythmic events were evaluated in 14 weeks old male hereditary insulin-resistant Otsuka Long-Evans Tokushima fatty (OLETF) rats and control Long-Evans Tokushima Otsuka (LETO) rats. OLETF rats showed longer correct sinus node recovery time. The mRNA levels of HCN4, RyR2, and phospholamban were downregulated in OLETF rats compared with LETO rats (p<0.01). SAN dysfunction in insulin-resistant rats was associated with malfunction of both membrane clock and Ca clock.

  • Research Products

    (8 results)

All 2014 2013

All Journal Article (3 results) Presentation (5 results)

  • [Journal Article] Combination therapy of cilostazol and bepridil suppresses recurrent ventricular fibrillation related to J-wave syndromes2014

    • Author(s)
      Shinohara T, Ebata Y, Ayabe R, Fukui A, Okada N, Yufu K, Nakagawa M, Takahashi N
    • Journal Title

      Heart Rhythm

      Volume: (in press)

  • [Journal Article] Carvedilol analog modulates both basal and stimulated sinoatrial node automaticity2014

    • Author(s)
      Shinohara T, Kim D, Joung B, Maruyama M, Vembaiyan K, Back TG, Wayne Chen SR, Chen PS, Lin SF
    • Journal Title

      Heart Vessels

      Volume: 29 Pages: 396-403

  • [Journal Article] Role of leptin signaling in the pathogenesis of angiotensin II-mediated atrial fibrosis and fibrillation2013

    • Author(s)
      Fukui A, Takahashi N, Nakada C, Masaki T, Kume O, Shinohara T, Teshima Y, Hara M, Saikawa T
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 6 Pages: 402-409

  • [Presentation] Hyperleptinemia Exacerbates High Fat Diet-mediated Atrial Remodeling and Fibrillation2014

    • Author(s)
      Fukui A, Kondo H, Saito S, Nishi S, Shinohara T, Teshima Y, Saikawa T, Takahashi N
    • Organizer
      日本循環器学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20140300
  • [Presentation] Role of Spleen-Derived Interleukin-10 in High-Fat-Diet-Induced Inflammatory Atrial Fibrosis and Fibrillation2014

    • Author(s)
      Kondo H, Takahashi N, Saito S, Fukui A, Nishio S, Aoki K, Shinohara T, Teshima Y, Hara M, Saikawa T
    • Organizer
      日本循環器学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20140300
  • [Presentation] Interleukin-10 Treatment Attenuayes Sinus Node Dysfunction and Atrial Fibrillation Vulnerability Caused by Streptozotocin-Induced Hyperglycemia2014

    • Author(s)
      Kondo H, Saito S, Fukui A, Nishio S, Shinohara T, Teshima Y, Takahashi N
    • Organizer
      日本循環器学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20140300
  • [Presentation] Insulin-resistance modulate both Membrane clock and Ca2+ clock leading to sinus node dysfunction2014

    • Author(s)
      Fukui A, Shinohara T, Takahashi N, Kondo H, Saito S, Teshima Y, Hara M, Saikawa T
    • Organizer
      日本循環器学会総会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20140300
  • [Presentation] Role of Leptin Signaling in Pathogenesis of Atrial Fibrosis and Fibrillation2014

    • Author(s)
      Fukui A, Takahashi N, Shinohara T, Saikawa T
    • Organizer
      日本循環器学会総会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20140300

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Published: 2015-06-25  

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