2012 Fiscal Year Final Research Report
Properties of the L-type Ca^channel and its mutants
| Project/Area Number |
23790251
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kagoshima University |
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Principal Investigator |
MINOBE Etsuko 鹿児島大学, 大学院・医歯学総合研究科, 助教 (00448581)
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| Research Collaborator |
MORI Masayuki 京都大学, 大学院・工学研究科, 准教授 (80342640)
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| Project Period (FY) |
2011 – 2012
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| Keywords | カルシウムチャネル / カルモジュリン / パッチクランプ法 / inside-out / ATP / run-down / リン酸化 |
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| Research Abstract |
Properties of the L-type Ca^channel and its mutants were explored using inside-out patch-clamp technique. Activity of these channels was induced by calmodulin plus ATP. A protein phosphatase inhibitor okadaic acid could substitute for ATP in wild-type channels, but it not in the mutant channels. It was suggested that the effects of ATP and okadaic acid, although apparently similar, were mediated by different mechanisms.
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[Presentation] Effects of 14 and 28 days exposure of human neuro cells in Space; Neuro Rad Experiments2011
Author(s)
Hiroko P. Indo, Noriaki Ishioka, Hiromi Suzuki, Toru Shimazu, Sachiko Yano, Fumiaki Tanigaki, Aiko Nagamatsu, Daisuke Masuda, Etsuko Minobe, Masaki Kameyama, Hideyuki J. Majima
Organizer
SFRBM's 18th Annual Meeting
Place of Presentation
Atlanta
Year and Date
20111116-20
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