2013 Fiscal Year Final Research Report
The involvement of astrocytes in the synaptic formation
Project/Area Number |
23790257
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General physiology
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Research Institution | Meiji Pharmaceutical University |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Keywords | 分子・細胞生理学 / ニューロン―グリア相互作用 / 神経科学 / 脳・神経 |
Research Abstract |
The purpose of this study was to analyze the involvement of astrocytes in the synaptic formation in brain. We established with success a visualization of synaptic formation and a mRNA collection from the target cells in vivo. Using analysis of microarray gene expression data, it was also found that Foxh1 gene, which interacts with SMAD signaling, and its target molecules were over-expressed in the astrocytes derived from the model mice.
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[Journal Article] Three mechanisms assemble central nervous system nodes of Ranvier2013
Author(s)
Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN
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Journal Title
Neuron
Volume: 78
Pages: 469-482
Peer Reviewed
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