2012 Fiscal Year Final Research Report
The investigation and identification of key molecules in the calciumoscillation-independent osteoclastogenesis
| Project/Area Number |
23790265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Keio University |
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Principal Investigator |
KURODA Yukiko 慶應義塾大学, 医学部, 特任助教 (70455343)
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| Project Period (FY) |
2011 – 2012
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| Keywords | シグナル伝達・分化 / 破骨細胞 / リン酸化 / イノシトール三リン酸受容体 / NFATc1 / Cot kinase |
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| Research Abstract |
In this study, I found that direct contact between osteoclasts and osteoblasts,especially membrane fraction molecule(s) of osteoblasts, is required for the inductionof Ca^<2+>oscillation-independent osteoclastogenesis. Moreover, I revealed that Cot, aseri
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