2012 Fiscal Year Final Research Report
Regulatory mechanism in hypothalamus to enhance glucose metabolism in peripheral tissues by leptin
| Project/Area Number |
23790282
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
TODA Chitoku 生理学研究所, 発達生理学研究系, NIPS リサーチフェロー (70571199)
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| Project Period (FY) |
2011 – 2012
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| Keywords | レプチン / 視床下部 / 腹内側核 / インスリン感受性 / 肝臓 / 筋肉 |
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| Research Abstract |
We found that letpin enhances insulin sensitivity in muscle and liver. MEK/ERK pathway and Jak/STAT3 pathway activated by leptin in the ventromedial hypothalamus (VMH) is required for the enhancement of insulin sensitivity in muscle and liver, respectively. After the activation of the VMH neuron by leptin, activation of POMC neuron in the arcuate nucleus in the hypothalamus and subsequent secretion of neuropeptide, alpha-MSH, toward VMH is important for the effect of leptin in muscle.
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[Journal Article] Extracellular Signal-Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle2013
Author(s)
Toda C, Shiuchi T, Kageyama H, Okamoto S, Coutinho EA, Sato T, Okamatsu-Ogura Y, Yokota S, Takagi K, Tang L, Saito K, Shioda S, Minokoshi Y.
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