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2013 Fiscal Year Final Research Report

Analysis of therapeutic mechanisms of Bushi by using in vivo imaging

Research Project

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Project/Area Number 23790287
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General pharmacology
Research InstitutionUniversity of Yamanashi

Principal Investigator

SHIBATA Keisuke  山梨大学, 医学工学総合研究部, 助教 (50580411)

Project Period (FY) 2011 – 2013
Keywords神経障害性疼痛 / in vivo イメージング / グリア細胞 / 一次体性感覚野 / 生薬・漢方薬
Research Abstract

The aim of this study is to clarify an involvement of glial functions in the somatosensory cortex (S1) in the pathogenesis of neuropathic pain. Using in vivo 2 photon microscopy, I investigated chronologic time-courses of Ca2+ activities in S1 cortical astrocytes both in control and neuropathic pain model animals (SNL; spinal nerve ligation), in parallel with pain behaviors (allodynia). I found that (1) Ca2+ activities in S1 cortex was enhanced by SNL, (2) receptor X was re-awaken in S1 astrocytes, and (3) neuropathic pain was dependent on both (1) and (2). These data strongly suggest that abnormal Ca2+ activities in S1 astrocytes, and subsequent events should be involved in the cause or the development of neuropathic pain.

  • Research Products

    (5 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice2011

    • Author(s)
      Keisuke Shibata, Takeshi Sugawara T, Kayoko Fujishita, Youichi Shinozaki, Takashi Matsukawa, Tsutomu Suzuki, Schuichi Koizumi
    • Journal Title

      PLoS One

      Volume: 6(8) Pages: e23510

    • Peer Reviewed
  • [Presentation] 小泉修一生薬ブシ末は活性化アストロサイトを抑制図2.受容体Xのアゴニストを処置したときのS1アストロサイトのCa2+応答して慢性化した神経障害性疹痛を緩解する2012

    • Author(s)
      柴田圭輔、菅原健、藤下加代子、篠崎陽一、鈴木勉
    • Organizer
      第14回応用薬理シンポジウム
    • Place of Presentation
      山梨ベルクラシック甲府
    • Year and Date
      20120903-04
  • [Presentation] 神経障害性疹痛におけるグリア細胞の役割と生薬ブシ末の鎮痛メカニズム2012

    • Author(s)
      柴田圭輔
    • Organizer
      日本東洋医学会関東甲信越支部山梨県部会
    • Place of Presentation
      山梨玉穂ふれあい診療所(口頭発表)
    • Year and Date
      2012-01-28
    • Invited
  • [Presentation] The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice2011

    • Author(s)
      Keisuke Shibata, Takeshi Sugawara, Kayoko Fujishita, Youichi Shinozaki, Takashi Matsukawa, Tsutomu Suzuki and Schuichi Koizumi
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington D.C
    • Year and Date
      20111112-16
  • [Presentation] The astrocyte-targeted therapy by Bushi for the neuropathic pain2011

    • Author(s)
      Keisuke Shibata, Takeshi Sugawara, Kayoko Fujishita, Youichi Shinozaki, Takashi Matsukawa, Tsutomu Suzuki and Schuichi Koizumi
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシブィコ横浜(Oral presentation)
    • Year and Date
      20110914-17

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Published: 2015-06-25  

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