2013 Fiscal Year Final Research Report
Analysis of therapeutic mechanisms of Bushi by using in vivo imaging
| Project/Area Number |
23790287
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
SHIBATA Keisuke 山梨大学, 医学工学総合研究部, 助教 (50580411)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 神経障害性疼痛 / in vivo イメージング / グリア細胞 / 一次体性感覚野 / 生薬・漢方薬 |
|---|
| Research Abstract |
The aim of this study is to clarify an involvement of glial functions in the somatosensory cortex (S1) in the pathogenesis of neuropathic pain. Using in vivo 2 photon microscopy, I investigated chronologic time-courses of Ca2+ activities in S1 cortical astrocytes both in control and neuropathic pain model animals (SNL; spinal nerve ligation), in parallel with pain behaviors (allodynia). I found that (1) Ca2+ activities in S1 cortex was enhanced by SNL, (2) receptor X was re-awaken in S1 astrocytes, and (3) neuropathic pain was dependent on both (1) and (2). These data strongly suggest that abnormal Ca2+ activities in S1 astrocytes, and subsequent events should be involved in the cause or the development of neuropathic pain.
|
Research Products
(5 results)
