2012 Fiscal Year Final Research Report
The analysis of functional and structural changes of the cell membrane induced by flavonoids to exhibit cytoprotective effects
| Project/Area Number |
23790292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | フラボノイド / heme oxygenase-1 / 細胞膜 |
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| Research Abstract |
The variety of the cytoprotective effects of flavonoids is assumed to inhibit common molecular mechanisms. In this study, I investigated the functional and structural changes ofthe cell membrane by quercetin, one of the flavonoids, to elucidate the molecular mechanisms of inhibitory effect of flavonoids. I showed the possibilities that quercetin translocated PLD to plasma membrane and induced the expression of HO-1 which is the key molecule to exhibit cytoprotective effects.
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