2013 Fiscal Year Final Research Report
A role of protein kinase C on formation and function of signalosome
| Project/Area Number |
23790293
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | シグナロソーム / スフィンゴシン１－リン酸 / スフィンゴシンキナーゼ / スフィンゴシン１－リン酸受容体 / プロテインキナーゼC / エクソソーム / 分子生物学 / 細胞生物学 |
|---|
| Research Abstract |
Exosomes are small membrane-bound vesicles released from a variety of physiological cells or tumor cells and include much functional proteins and RNAs as cargo. Recently exosomes are attracting worldwide attention as new intercellular communication tool that participates as physiological or pathological events. However the detailed mechanism underlying cargo sorting into exosome is still unclear. Here, first in the world, we made clear that "sphingosine kinase signalosome" triggers the sorting of cargo molecules into exosomes. By the result of this study, the "sphingosine kinase signalosome"-related molecules are expected as an innovative drug development target of various diseases that exosome participates in.
|
