2012 Fiscal Year Final Research Report
Functional analysis and pathological roles of HIF-1α in vascular remodeling
| Project/Area Number |
23790298
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ISHIZAWA Keisuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60398013)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血管リモデリング / 動脈硬化 / 血管平滑筋細胞 / Hypoxia inducible factor / アンジオテンシン II |
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| Research Abstract |
It was revealed that Hif-1αis a crucial mediator of angiotensin II (Ang II)-induced vascular remodeling, using mice lacking theHif-1α gene in smooth muscle cells (SMKO mice).
1, Chronic Ang II infusion induced medial thickness and vascular fibrosis in aortae of control mice, but not in SMKO mice.
2, The expression of genes related to fibrosis and inflammation was induced by Ang II in control mice, but not in SMKO mice.
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