2012 Fiscal Year Final Research Report
ATP/adenosine as a critical link between altered metabolism and neuronal activity
| Project/Area Number |
23790303
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | アデノシン受容体 / ケトン食療法 / てんかん |
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| Research Abstract |
The “cause-and-effect” relationship between altered metabolism and the neurological conditions are not fully understood yet. We hypothesized that ATP/adenosine might play a specific role in modulating neuronal activity to produce the anticonvulsant effects of the ketogenic diet. We found that ketogenic diet-induced antiseizure effect is caused by ATP release with the subsequent activation of adenosine A_1 receptors.
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