2012 Fiscal Year Final Research Report
The role of aquaporin in the intestine in water transport
| Project/Area Number |
23790306
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | アクアポリン / 下痢 / 便秘 / 大腸 / 下剤 |
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| Research Abstract |
We investigated the role of aquaporin-3 (AQP3) in the intestine in water transport.In this study, it has been revealed that the fecal water content in the colon is controlled by the transport of water from the luminal side to the vascular side, which is mediated by AQP3. Thus, new laxatives and antidiarrheals targeting intestinal AQP3 may be developed in the future.
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Research Products
(9 results)
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[Journal Article] The concomitant use of an osmotic laxative, magnesium sulphate, and a stimulant laxative, bisacodyl, does not enhance the laxative effect2012
Author(s)
N.Ikarashi, A.Mimura, R.Kon, T.Iizasa, M.Omodaka, C.Nagoya, M.Ishii, T.Toda, W.Ochiai, and K.Sugiyama.
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Journal Title
Eur. J. Pharm. Sci.
Volume: 45
Pages: 73-78
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[Journal Article] Ochiai, and K. Sugiyama. Inhibition of aquaporin-3 water channel in the colon induces diarrhea2012
Author(s)
N.Ikarashi, R.Kon, T.Iizasa, N.Suzuki, R.Hiruma, K.Suenaga, T.Toda, M.Ishii, M.Hoshino, W.
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Journal Title
Biol. Pharm. Bull.
Volume: 35
Pages: 957-962
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[Journal Article] A mechanism by which the osmotic laxative magnesium sulphate increases the intestinal aquaporin 3 expression in HT-29 cells2010
Author(s)
N.Ikarashi, T.Mochiduki, A.Takasaki, T.Ushiki, K. Baba, M.Ishii, T.Kudo, K.Ito, T.Toda, W. Ochiai, and K.Sugiyama
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Journal Title
Life Sci.
Volume: 88
Pages: 194-200
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