2012 Fiscal Year Final Research Report
Autophagy is a candidate process of the endogenous cardioprotective function in the diabetic cardiomyopathy
| Project/Area Number |
23790307
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Gunma University (2012)
Musashino University (2011) |
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Principal Investigator |
MIYATA Shigeo 群馬大学, 大学院・医学系研究科, 助教 (40366836)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 循環器 / 高血圧 / 糖尿病 |
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| Research Abstract |
We evaluated the autophagic activity in the heart of TSOD mice. The expression levels of autophagy-related proteins (Atg5-Atg12 conjugate and K63-linked polyubiquitinated proteins) were higher in the heart of TSOD mice than the non-diabetic control. However, pre-diabetic TSOD mice did not show any change in the heart. We suggest that autophagy is a candidate process of the endogenous cardioprotective function inTSOD mice.
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