2012 Fiscal Year Final Research Report
The involvementof TRPC3 channelsinthe anti-cancer drug-induced peripheral neuropathy
| Project/Area Number |
23790315
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
MIYANO Kanako 独立行政法人国立がん研究センター, 研究所, 研究員 (50597888)
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| Project Period (FY) |
2011 – 2012
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| Keywords | TRPチャネル / 疼痛 / 抗がん剤 / 末梢神経障害 |
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| Research Abstract |
The object of this study is to reveal the role of TRPC3 channel on cancer patientswithsevere pain. The present study is focused on the chemotherapy-induced peripheral neuropathy. We examinedthe expression levelsof TRPC3 protein and analgesic effects of a TRPC3 antagonist poyrazole-3 using anti-cancer drugcarboplatin-induced neuropathic pain model mice. The resultsshowed that the expression levelsof TRPC3 protein spinal cord dorsal hornand dorsal root ganglion fromcarboplatin-induced neuropathic pain model mice did not change. However, pyrazole-3 suppressed the carboplatin-inducedneuropathic pain. These findingssuggest that the activation of TRPC3, but not the expression levels of TRPC3 could beinvolvedin the carboplatin-induced neuropathic pain.
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[Journal Article] Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice.2012
Author(s)
Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashikawa M, Miyano K, Yanagihara K, Chiwaki F, Ochiya T, Suzuki T, Matoba M, Sasaki H, Uezono Y.
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Journal Title
Anesthesiology
Volume: 117
Pages: 847-856
URL
Peer Reviewed
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[Presentation] Ghrelin resistance in a novel cancer cachexia model and its effects of Rikkunshito by enhancement of ghrelin signaling2013
Author(s)
Terawaki K, Kashiwase Y, Sawada Y, Suzuki M, Miyano K, Sudo Y, Shiraishi S, Higami Y, Kase Y, Yanagihara K, Uezono Y
Organizer
The Japanese Pharmacological Society
Place of Presentation
Fukuoka/Japan
Year and Date
20130321-23
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[Presentation] Development and screening of noveldelta opioid receptor-specific agonists with a label-free, cell-impedance-based CellKey^<TM> system2013
Author(s)
Yokoyama A, Sudo Y, Miyano K, Suzuki M, Shiraishi S, Hirayama S, Hayashida K, Fujii H, Sakai J, Kanda T, Nakata E, Nagase H, Higami Y, Uezono Y
Organizer
The Japanese PharmacologicalSociety
Place of Presentation
Fukuoka/Japan
Year and Date
20130021-23
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[Presentation] Establishment of novel animal models of cancer cachexia by transplantation of human gastric cancer cell lines and effects of rikkunshito, a traditional Japanese medicine, on the cancer cachexia models2011
Author(s)
Terawaki K, Yanagihara K, Sawada Y, Kashiwase Y, Suzuki M, Miyano K, Sudo Y, Shiraishi S, Uezono Y
Organizer
6th Cachexia Conference
Place of Presentation
Milan/Italy
Year and Date
2011-12-09
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[Presentation] ラベルフリーで細胞機能をアッセイ出来るシステム、Cellkey^<TM>を用いた各種GPCR,Ionchannelの活性評価2011
Author(s)
上園保仁,須藤結香,宮野加奈子,柏瀬陽平,澤田祐美,寺脇潔,鈴木雅美,小柳尚史,樋上賀一,白石成二
Organizer
第64回日本薬理学会西南部会
Place of Presentation
第64回日本薬理学会西南部会
Year and Date
2011-11-20
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