2012 Fiscal Year Final Research Report
The elucidation of the humoral immunity control mechanism by heme
| Project/Area Number |
23790320
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MATSUI Miki 東北大学, 大学院・医学系研究科, 助手 (00455784)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生体分子医学 / 転写因子 / ヘム |
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| Research Abstract |
The transcriptional repressor Bach2 possesses the basic region-leucine zipper (bZip) motif that mediates dimer formation with Maf oncoproteins and DNA binding. It has been found that heme inhibits the DNA binding activity of Bach2 in vitro.and induces degradation of Bach2 in B cells. To reveal the molecular mechanism of the heme-mediated regulation of Bach2, we mapped the heme-binding region by using spectroscopic analyses. Moreover, the results of various instrumental analysis of Bach2 revealed that the unstructured region of Bach2 is important for heme binding and/or transducing heme effect upon the functional regulation of Bach2.
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[Journal Article] Heme regulates B cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach22011
Author(s)
M. Watanabe-Matsui, A. Muto, T. Matsui, A. Itoh-Nakadai, O. Nakajima, K. Murayama, M. Yamamoto, M. Ikeda-Saito, and K. Igarashi
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Journal Title
Blood
Volume: 117
Pages: 5438-5448
DOI
Peer Reviewed
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