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2012 Fiscal Year Final Research Report

Studies of chromatin architectural protein HMGN3 in pancreaticbeta-cell

Research Project

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Project/Area Number 23790323
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionYamagata University

Principal Investigator

KURAHASHI Toshihiro  山形大学, 大学院・医学系研究科, 助教 (00596570)

Project Period (FY) 2011 – 2012
KeywordsHMGN / クロマチン / 膵β細胞
Research Abstract

We studied physiological roles of high mobility group N (HMGN) and obtained following results. (1) HMGN3 was highly expressed in pancreatic endocrine cells, and -knockout mouse showed a diabetic phenotype. (2) HMGN3 might interact with a splicing factor. (3) Overexpression of HMGN3 affected the gene expression little in fibroblast but largely in pancreatic beta cell-derived cell. (4) Opposite results were obtained by overexpression of HMGN3 in these cells. HMGN1 interacted with PCNA and facilitated its binding to chromatin.

  • Research Products

    (6 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice2012

    • Author(s)
      Kurahashi T, Konno T, Otsuki N, Kwon M, Tsunoda S, Ito J, Fujii J
    • Journal Title

      FEBS Lett

      Volume: 586 (24) Pages: 4289-95

    • DOI

      DOI:10.1016/j.febslet

    • Peer Reviewed
  • [Journal Article] The Nucleosome Binding Protein HMGN1 Interacts with PCNA and Facilitates its Binding to Chromatin2012

    • Author(s)
      Postnikov VY, Kurahashi T, (contribute equally) Zhou M and Bustin M
    • Journal Title

      Mol Cell Biol

      Volume: 32(10) Pages: 1844-54

    • DOI

      DOI:10.1128/MCB.06429-11

    • Peer Reviewed
  • [Journal Article] Effects of HMGN variants on the cellular transcription profile2011

    • Author(s)
      Rochman M, Taher L, Kurahashi T, Cherukuri S,Landsman D,Ovcharenko I and Bustin M
    • Journal Title

      Nucleic Acid Res

      Volume: 39(10) Pages: 4076-87

    • DOI

      DOI:10.1093/nar/gkq1343

    • Peer Reviewed
  • [Presentation] 酸化ストレス亢進による小腸の脂質代謝異常2012

    • Author(s)
      倉橋敏裕ら
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡、福岡国際会議場・マリンメッセ福岡
    • Year and Date
      20121200
  • [Presentation] SOD1 deficiency causes postprandial dyslipidemia due to impaired lipid metabolism in the intestine2012

    • Author(s)
      Kurahashi, T, et al
    • Organizer
      16th Biennial Meeting of Society for Free Radical Research International
    • Place of Presentation
      Imperial College, London, UK, Sep
    • Year and Date
      20120900
  • [Presentation] SOD1欠損マウス小腸における脂質代謝の解析2012

    • Author(s)
      倉橋敏裕ら
    • Organizer
      第65回日本酸化ストレス学会学術集会
    • Place of Presentation
      徳島、徳島郷土文化会館
    • Year and Date
      20120600

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Published: 2014-09-25  

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