2012 Fiscal Year Final Research Report
Analysis of Histon modification and higher-order structure that regulate pluripotency of iPS cells
| Project/Area Number |
23790329
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
SONE Masamitsu 京都大学, iPS 細胞研究所, 研究員 (90599771)
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| Research Collaborator |
IKEDA Hiroki 京都大学, 医学研究科, 博士後期課程
KABATA Mio 京都大学, iPS 細胞研究所, 技術補佐員
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| Project Period (FY) |
2011 – 2012
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| Keywords | クロマチン高次構造 / ヒストン修飾 / iPS 細胞 / 多能性幹細胞 / 次世代シーケンサー |
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| Research Abstract |
Using a high-throughput analysis, we revealed that chromatinarchitectures in the promoter regions of specific genes are different between somatic cells and iPS cells. It may indicate important molecular mechanisms for acquisition of pluripotency.
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