2012 Fiscal Year Final Research Report
Regulation of lamellipodial dynamics by oscillation of Rac1 activity
| Project/Area Number |
23790335
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞内情報伝達 |
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| Research Abstract |
It has been reported that Rac, one of Rho-family small GTPase, plays an important role in formation of lamellipodia. However, the regulatory mechanism of Rac activity remains unknown. In this study, it becomes clear that srGAP1 regulates lamellipodial dynamics through the control of Rac activity. The proper control of Rac activity at laemllipodia is important for efficient migration.
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