2012 Fiscal Year Final Research Report
Increase in skeletal muscle amount by an attenuation of PIP3 phosphatase SKIP
| Project/Area Number |
23790336
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
IJUIN Takeshi 神戸大学, 大学院・医学研究科, 助教 (00361626)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨格筋 / PI3キナーゼ / SKIP / IGF-1 / 筋量増強 |
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| Research Abstract |
In this study, we revealed that skeletal muscle and kidney enriched inositol polyphosphate 5-phosphatase (SKIP) negatively regulated insulin-like growth factor (IGF)-1 signal in the skeletal muscle. SKIP inhibited IGF-1 mediated protein synthesis and hypertrophy through the negative regulation of PI 3-kinase signaling pathway. Together with the results that SKIP heterozygous knockout mice exhibited increased amount of tibialis anterior skeletal muscle, SKIP is likely to be a key factor that trigger hypotrophy of skeletal muscle. Thus, SKIP may be a promising target for the intervention of hypotrophy accompanied by several severe diseases including cancer cachexia.
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