Analysis of the molecular mechanisms which underlies the dynamiccharacteristics of regulatory T cell function

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790346
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Keio University
• Principal Investigator: SEKIYA Takashi 慶應義塾大学, 医学部, 助教 (80519207)
• Project Period (FY): 2011 – 2012
• Keywords: 免疫学 / 細胞分化

Research Abstract

During their development in the thymus, self-reactive T cells areeither eliminated by apoptosis or differentiated into regulatory T cells. This developmentalsystem plays crucial roles in prevention of autoimmune diseases, however, the underlyingmolecular

Research Products

• [Journal Article] Nr4a receptors are essential for thymicregulatory T cell development and immunehomeostasis. (2013)
  • Author(s): Takashi Sekiya, Ikkou Kashiwagi, ReiYoshida, Tomohiro Fukaya, Rimpei Morita,Akihiro Kimura, Hiroshi Ichinose, DanielMetzger, Pierre Chambon, Akihiko Yoshimura
  • Journal Title: Nature Immunology Volume: 14巻 Pages: 230-237
  • DOI: doi:10.1038/ni.2520
  • Peer Reviewed
• [Journal Article] The nuclear orphan receptor Nr4a2 induceseFoxp3 and regulates differentiation of CD4^+T cells (2011)
  • Author(s): Takashi Sekiya, Ikkou Kashiwagi, NaokoInoue, Rimpei Morita, Shohei Hori, HermanWaldmann, Alexander Y. Rudensky, HiroshiIchinose, Daniel Metzger, Pierre Chambon,Akihiko Yoshimura
  • Journal Title: Nature Communications Volume: 2巻 Pages: 269
  • DOI: DOI:10.1038/ncomms1272
  • Peer Reviewed
• [Presentation] Regulation of CD4 T cell differentiationand inflammatory diseases by the nuclearorphan receptor Nr4a2 (2012)
  • Author(s): 関谷 高史、吉村 昭彦
  • Organizer: 第41回日本免疫学会学術集会総会
  • Place of Presentation: 神戸
  • Year and Date: 20121205-07
• [Presentation] Roles of the nuclear orphan receptor Nr4a2in regulation of CD4+ T celldifferentiation and inflammatorydiseases (2012)
  • Author(s): Takashi Sekiya and Akihiko Yoshimura
  • Organizer: Keystone Symposia: The Biology of Cytokines
  • Place of Presentation: Colorado (USA)
  • Year and Date: 20120205-10
• [Presentation] 核内オーファン受容体Nr4a2によるCD4T細胞分化と自己免疫疾患の制御 (2011)
  • Author(s): 関谷 高史、吉村 昭彦
  • Organizer: 第40回日本免疫学会学術集会総会
  • Place of Presentation: 千葉
  • Year and Date: 20111127-29
• [Book] Nr4a2によるFoxp3の誘導機構臨床免疫・アレルギー、57 巻 (2012)
  • Author(s): 関谷 高史, 吉村 昭彦
  • Total Pages: 360-366
  • Publisher: 科学評論社