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2012 Fiscal Year Final Research Report

The neural circuit for dopaminergic system regulation by Notch signaling

Research Project

  • PDF
Project/Area Number 23790350
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research Institution滋賀県立成人病センター研究所 (2012)
Research Institute, Shiga Medical Center (2011)

Principal Investigator

TANIGAKI Kenji  滋賀県立成人病センター研究所, 専門研究員 (70362473)

Project Period (FY) 2011 – 2012
Keywords高次生命医学
Research Abstract

Notch/RBP-J signaling regulates neural development at multiple stages. We utilized RBP-J conditional knockout mice and found that neuron-specific loss of RBP-J, a main mediator of Notch signaling, causes the deficits in the dopaminergic responsiveness. To elucidate which neural circuit is responsible for Notch -dependent control of Dopaminergic signaling, we examined the sites of Notch signaling activation in the central nervous system.

  • Research Products

    (10 results)

All 2013 2012 2011 Other

All Journal Article (5 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Notch signaling regulates nucleocyt oplasmic Olig2 translocation in rea ctive astrocytes differentiation of ter ischemic stroke2013

    • Author(s)
      Marumo T, Takagi Y, Muraki K, Hashi moto N, Miyamoto S, Tanigaki K
    • Journal Title

      Neurosci Res

      Volume: (Epub ahead of print)

  • [Journal Article] Selective overexpression of Comt in prefrontal cortex rescues schizo phrenia-like phenotypes in a mouse model of 22q11 deletion syndrome2012

    • Author(s)
      Kimoto S, Muraki K, Toritsuka M, Mu gikura S, Ka j iwara K, Kishimoto T, Illingworth E, Tanigaki K
    • Journal Title

      Transl Psychiatry

      Pages: e146

    • DOI

      doi:10. 1038/tp. 2012. 70

  • [Journal Article] Alterations of social interaction t hrough genetic and environmental ma nipulation of the 22q11.2 gene Sept 5 in the mouse brain2012

    • Author(s)
      Harper KM, Hiramoto T, Tanigaki K, Kang G, Suzuki G, Trimble W, Hiroi N
    • Journal Title

      Hum Mol Genet

      Volume: 21(15) Pages: 3489-99

  • [Journal Article] Localization of septin proteins in the mouse cochlea2012

    • Author(s)
      Yoshida A, Yamam oto N, Kinoshita M, Hiroi N, Hiramo to T, Kang G, Trimble WS, Tanigaki K, Nakagawa T, Ito
    • Journal Title

      J. Hear Res

      Volume: 289 (1-2) Pages: 40-51

  • [Journal Article] Notch signaling regulates the d evelopment of a novel type of T hy1-expressing dendritic cell i n the thymus2011

    • Author(s)
      Ishifune C, Maekawa Y, Nishida J, Kitamura A, Tanigaki K, Yagi to H, Yasutomo K
    • Journal Title

      Eur J Immunol

      Volume: 41 (5) Pages: 1309-20

  • [Presentation] Rescue of behavioral abnormalitie s of 22g11.2 deletion syndrome mo del mice by prefrontal cortex-spe cific COMT overexpression2012

    • Author(s)
      Kenji Tanigaki
    • Organizer
      第35回神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20120918-21
  • [Presentation] Neuropathological analysis of 22q11.2 deletion syndrome model mice2011

    • Author(s)
      Kenji Tanigaki
    • Organizer
      The 32nd Naito Conferece on Biol ogical basis of mental functions and disorders
    • Place of Presentation
      八ケ岳
    • Year and Date
      2011-10-19
  • [Presentation] Behavioral Analysis of Neuron-specific RBP-J knockout mice2011

    • Author(s)
      Kenji Tanigaki
    • Organizer
      The Notch Meeting
    • Place of Presentation
      Greece
    • Year and Date
      2011-10-05
  • [Presentation] Neuropathological analysis of 22q 11.2 deletion syndrome model mice2011

    • Author(s)
      谷垣健二
    • Organizer
      第34回 神経科学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
  • [Remarks]

    • URL

      http://www.shigamed..jp/divisions /neuron. Html

URL: 

Published: 2014-09-25  

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