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2012 Fiscal Year Final Research Report

Molecular basis of Rab27 GTPase-mediated regulated exocytosis

Research Project

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Project/Area Number 23790354
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionGunma University

Principal Investigator

MATSUNAGA Kohichi  群馬大学, 生体調節研究所, 助教 (20570162)

Project Period (FY) 2011 – 2012
Keywordsβ細胞 / Rab27 / 調節性分泌
Research Abstract

To investigate the molecular mechanism of Rab27 GTPase-mediated regulated exocytosis, I performed comprehensive proteomic analysis of Rab27a binding proteins in various secreting cells. I identified dozens of novel Rab27a binding proteins and also identified cell strain specific binding proteins. Therefore, I obtained basic data to clarify the molecular mechanism for regulating Rab27-mediated exocytosis pathway.

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Published: 2014-09-25   Modified: 2015-11-04  

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