2012 Fiscal Year Final Research Report
Molecular basis of Rab27 GTPase-mediated regulated exocytosis
| Project/Area Number |
23790354
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | β細胞 / Rab27 / 調節性分泌 |
|---|
| Research Abstract |
To investigate the molecular mechanism of Rab27 GTPase-mediated regulated exocytosis, I performed comprehensive proteomic analysis of Rab27a binding proteins in various secreting cells. I identified dozens of novel Rab27a binding proteins and also identified cell strain specific binding proteins. Therefore, I obtained basic data to clarify the molecular mechanism for regulating Rab27-mediated exocytosis pathway.
|
